This is the Editorial of the Research Topic (Special Issue) in Frontiers in Psychology and Frontiers in Neurorobotics: Intrinsic motivations and open-ended development in animals, humans, and robots.

Human cooperation is highly unusual. We live in large groups composed mostly of non-relatives. Evolutionists have proposed a number of explanations for this pattern, including cultural group selection and extensions of more general processes such as reciprocity, kin selection, and multi-level selection acting on genes. Evolutionary processes are consilient; they affect several different empirical domains, such as patterns of behavior and the proximal drivers of that behavior. In this target article, we sketch the evidence from five domains that bear on (...) the explanatory adequacy of cultural group selection and competing hypotheses to explain human cooperation. Does cultural transmission constitute an inheritance system that can evolve in a Darwinian fashion? Are the norms that underpin institutions among the cultural traits so transmitted? Do we observe sufficient variation at the level of groups of considerable size for group selection to be a plausible process? Do human groups compete, and do success and failure in competition depend upon cultural variation? Do we observe adaptations for cooperation in humans that most plausibly arose by cultural group selection? If the answer to one of these questions is “no,” then we must look to other hypotheses. We present evidence, including quantitative evidence, that the answer to all of the questions is “yes” and argue that we must take the cultural group selection hypothesis seriously. If culturally transmitted systems of rules (institutions) that limit individual deviance organize cooperation in human societies, then it is not clear that any extant alternative to cultural group selection can be a complete explanation. (shrink)

Many have argued that early visual processing is encapsulated from the influence of higher-level goals, expectations, and knowledge of the world. Here we confront the main arguments offered in support of such a view, showing that they are unpersuasive. We also present evidence of top–down influences on early vision, emphasizing data from cognitive neuroscience. Our conclusion is that encapsulation is not a defining feature of visual processing. But we take this conclusion to be quite modest in scope, readily incorporated into (...) mainstream vision science. (shrink)

We generalize ordinary register machines on natural numbers to machines whose registers contain arbitrary ordinals. Ordinal register machines are able to compute a recursive bounded truth predicate on the ordinals. The class of sets of ordinals which can be read off the truth predicate satisfies a natural theory SO. SO is the theory of the sets of ordinals in a model of the Zermelo-Fraenkel axioms ZFC. This allows the following characterization of computable sets: a set of ordinals is ordinal register (...) computable if and only if it is an element of Gödel’s constructible universe L. (shrink)

Dans cet article, l'A. nous propose une solution à un vexant problème théologique, à savoir la façon dont la vision béatifique complète la nature humaine tout en demeurant un don au delà du don divin qui est notre être naturel. En se penchant sur l'oeuvre de Thomas d'Aquin, Ryan encadre d'abord le problème. Ensuite il étudie l'émergence de la théorie dite de «pure nature» comme réponse à Baius, lequel affirmait qu'avant la chute d'Adam la vision béatifique n'était que le (...) complément, dû nécessairement à la nature humaine. L'auteur nous présente également la défense offerte par Garrigou-Lagrange de la théorie de «pure nature», ainsi que la critique offerte par de Lubac. Nous remarquons effectivement que la prise de position des partisans de «pure nature» et celle adoptée par de Lubac se réfutent mutuellement. Ensuite nous étudions la position de Rahner. Selon Ryan, l'apport de Rahner est important; cependant une solution basée sur «l'existentiel surnaturel» rahnerien reste intenable. En fin de compte, l'auteur nous propose une solution qui tire profit de ces points de vue divergents, tout en évitant les pièges qui les accompagnent. (shrink)

The use of algorithms and automated systems, especially those leveraging artificial intelligence (AI), has been exploding in the public sector, but their use has been controversial. Ethicists, public advocates, and legal scholars have debated whether biases in AI systems should bar their use or if the potential net benefits, especially toward traditionally disadvantaged groups, justify even greater expansion. While this debate has become voluminous, no scholars of which we are aware have conducted experiments with the groups affected by these policies (...) about how they view the trade-offs. We conduct a set of two conjoint experiments with a high-quality sample of 973 Americans who identify as Black or African American in which we randomize the levels of inter-group disparity in outcomes and the net effect on such adverse outcomes in two highly controversial contexts: pre-trial detention and traffic camera ticketing. The results suggest that respondents are willing to tolerate some level of disparity in outcomes in exchange for certain net improvements for their community. These results turn this debate from an abstract ethical argument into an evaluation of political feasibility and policy design based on empirics. (shrink)

Thomas d'Aquin pense que tout homme dirige nécessairement toutes ses actions vers une fin ultime unique. L'article rejette cette position et son présupposé que tout homme cherche nécessairement une béatitude parfaite qui ne laisse rien à désirer. L'article affirme au contraire que les hommes agissent souvent de façon simultanée en vue de plus d'une fin dernière. Ceux qui pèchent mortellement le font en commettant des actions gravement mauvaises, tout en croyant et espérant en Dieu. Ceux qui vivent dans la grace (...) sont supposés avoir Dieu pour leur fin derniere unique. Cependant, tout péché véniel délibéré est commis pour une autre fin ultime. En fait, les gens posent souvent des actions moralement bonnes pour une fin ultime autre que Dieu, car la foi vivante n'informe pas automatiquement toute la vie. On doit apprendre à chercher d'abord le Royaume de Dieu, conçu comme incluant non seulement le bien infini mais aussi les biens créés dans lesquels les coeurs inquiets des hommes trouvent leur accomplissement intégral. (shrink)

The introduction and tracking of individuals over extended discourse, known as referential movement, is a central feature of coherence, and accounts for 'about every third word of discourse'. Located at the intersection of pragmatics and grammar, reference is now proving a rich and enduring source of insight into second language development. The challenge for L2 learners involves navigating the selection and positioning of reference in the target language, continually shifting and balancing the language used to maintain coherence, while remaining acutely (...) sensitive to the discourse and social context. The present volume focuses on how L2 learners meet that challenge, bringing together both eminent and up-and-coming researchers in the field of L2 acquisition. The chapters address a range of problems in SLA (e.g. form-function mapping, L1 influence, developmental trajectories), and do so in relation to various theoretical approaches to reference (e.g. Accessibility Theory, Givenness Hierarchy). The global outlook of these studies relate to the L2 acquisition of English, French, Japanese, Korean, and Spanish and cover a diverse range of situational contexts including heritage language learning, English as a Medium of Instruction, and the development of sociolinguistic competence. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Autonomy has been central to moral and political philosophy for millenia, and has been positioned as a critical aspect of both justice and wellbeing. Research in psychology supports this position, providing empirical evidence that autonomy is critical to motivation, personal growth and psychological wellness. Responsible AI will require an understanding of, and ability to effectively design for, human autonomy (rather than just machine autonomy) if it is to genuinely benefit humanity. Yet the effects on human autonomy of digital experiences are (...) neither straightforward nor consistent, and are complicated by commercial interests and tensions around compulsive overuse. This multi-layered reality requires an analysis that is itself multidimensional and that takes into account human experience at various levels of resolution. We borrow from HCI and psychological research to apply a model (“METUX”) that identifies six distinct spheres of technology experience. We demonstrate the value of the model for understanding human autonomy in a technology ethics context at multiple levels by applying it to the real-world case study of an AI-enhanced video recommender system. In the process we argue for the following three claims: 1) There are autonomy-related consequences to algorithms representing the interests of third parties, and they are not impartial and rational extensions of the self, as is often perceived; 2) Designing for autonomy is an ethical imperative critical to the future design of responsible AI; and 3) Autonomy-support must be analysed from at least six spheres of experience in order to approriately capture contradictory and downstream effects. (shrink)

Patients who experience difficulty making medical decisions are often referred to as “ambivalent.” However, the current lack of attention to the nuances between a cluster of phenomena that resemble...

Concerns about the risks of unmitigated greenhouse gas emissions are growing. At the same time, confidence that international policy agreements will succeed in considerably lowering anthropogenic greenhouse gas emissions is declining. Perhaps as a result, various geoengineering solutions are gaining attention and credibility as a way to manage climate change. Serious consideration is currently being given to proposals to cool the planet through solar-radiation management. Here we analyze how the unique and nontrivial risks of geoengineering strategies pose fundamental questions at (...) the interface between science and ethics. To illustrate the importance of integrated ethical and scientific analysis, we define key open questions and outline a coupled scientific-ethical research agenda to analyze solar-radiation management geoengineering proposals. We identify nine key fields of coupled research including whether solar-radiation management can be tested, how quickly learning could occur, normative decisions embedded in how different climate trajectories are valued, and justice issues regarding distribution of the harms and benefits of geoengineering. To ensure that ethical analyses are coupled with scientific analyses of this form of geoengineering, we advocate that funding agencies recognize the essential nature of this coupled research by establishing an Ethical, Legal, and Social Implications program for solar-radiation management. (shrink)

Promoting the use of contact tracing technology will be an important step in global recovery from the COVID-19 pandemic. Across two studies, we assessed two messaging strategies as motivators of intended contact tracing uptake. In one sample of 1117 Australian adults and one sample of 888 American adults, we examined autonomy-supportive and controlling message framing and the presence or absence of information safety as predictors of intended contact tracing application uptake, using an online randomized 2 × 2 experimental design. The (...) results suggested that the provision of data safety assurances may be key in affecting people’s intentions to use contact tracing technology, an effect we found in both samples regardless of whether messages were framed as autonomy-supportive or controlling. Those in high information safety conditions consistently reported higher intended uptake and more positive perceptions of the application than those in low information safety conditions. In Study 2, we also found that perceptions of government legitimacy related positively to intended application uptake, as did political affiliation. In sum, individuals appeared more willing to assent to authority regarding contact tracing insofar as their data safety can be assured. Yet, public messaging strategies alone may be insufficient to initiate intentions to change behavior, even in these unprecedented circumstances. (shrink)

This paper is about teaching philosophy to high school students through Lincoln-Douglas (LD) debate. LD, also known as “values debate,” includes topics from ethics and political philosophy. Thousands of high school students across the U.S. debate these topics in class, after school, and at weekend tournaments. We argue that LD is a particularly effective tool for teaching philosophy, but also that LD today falls short of its potential. We argue that the problems with LD are not inevitable, and we offer (...) strategic recommendations for improving LD as a tool for teaching philosophy. Ultimately, our aim is to create a dialogue between LD and academic philosophy, with the hope that such dialogue will improve LD’s capacity to teach students how to do philosophy. (shrink)

Questions about when to limit unhelpful treatments are often raised in general medicine but are less commonly considered in psychiatry. Here we describe a survey of U.S. psychiatrists intended to characterize their attitudes about the management of suicidal ideation in patients with severely treatment-refractory illness. Respondents (n = 212) received one of two cases describing a patient with suicidal ideation due to either borderline personality disorder or major depressive disorder. Both patients were described as receiving all guideline-based and plausible emerging (...) treatments. Respondents rated the expected helpfulness and likelihood of recommending each of four types of intervention: hospitalization, additional medication changes, additional neurostimulation, and additional psychotherapy. Across both cases, most respondents said they were likely to provide each intervention, except for additional neurostimulation in borderline personality disorder, while fewer thought each intervention would be helpful. Substantial minorities of respondents indicated that they would provide an intervention they did not think was likely to be helpful. Our results suggest that while most psychiatrists recognize the possibility that some patients are unlikely to be helped by available treatments, many would continue to offer such treatments. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

This paper surveys the evidence for the use of scientific and mathematical instruments from tenth-century Kiev Rus' to the death of Peter the Great in 1725 and the literature devoted to the subject. The evidence is extremely sparse before the sixteenth century; in the seventeenth century there is more, both in the form of artefacts, either local or imported, and texts; at the end of the seventeenth century and in the first quarter of the eighteenth century, Peter the (...) Great opted for complete Westernization, and both by edict and by creating a need for their products in effect established the instrument making and scientific book publishing trades in Russia. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

Ms. P. is in the ICU with respiratory failure and sepsis. She has been on a ventilator for almost a week, and now has impending kidney failure. Her children, who have been taking turns at the bedsi...

Our world is a world of change. Children are born and grow into adults. Material possessions rust and decay with age and ultimately perish. Yet scepticism about change is as old as philosophy itself. Heraclitus, for example, argued that nothing could survive the replacement of parts, so that it is impossible to step into the same river twice. Zeno argued that motion is paradoxical, so that nothing can alter its location. Parmenides and his followers went even further, arguing that the (...) very concept of qualitative change is inconsistent. Change in any respect is impossible, they argued, as change requires difference and nothing differs from itself. Few today would accept the Eleatic conclusion that change is impossible. But the topic of change continues to be a source of much debate, as it brings together various issues that are central to metaphysics, language, and logic – including identity, persistence, time, tense, and temporal logic. Author Recommends Wasserman, Ryan. 'The Problem of Change.' Philosophy Compass 1 (2006): 1–10. This article presents the problem of change and provides a brief survey of potential solutions. Haslanger, Sally. 'Persistence Through Time.' The Oxford Handbook of Metaphysics . Eds. M. Loux and D. Zimmerman. Oxford: Oxford University Press, 2003. This article presents the problem of change and provides a detailed survey of potential solutions. Heller, Mark. 'Things Change.' Philosophy and Phenomenological Research 52 (1992): 695–704. This article presents, explains, and defends the temporal parts solution to the problem of change. Hinchliff, Mark. 'The Puzzle of Change.' Philosophical Perspectives 10 (1996): 119–36. This article presents, explains, and defends the presentist solution to the problem of change. Wasserman, Ryan. 'The Argument from Temporary Intrinsics.' Australasian Journal of Philosophy 81 (2003): 413–19. This article presents, explains, and defends the relationist solution to the problem of change. Sider, Theodore. Four-Dimensionalism . Oxford: Oxford University Press, 2001. This book provides an introduction to various issues related to the problem of change, including the nature of time, tense, and persistence. Chapter 5 presents, explains, and defends the stage-view solution to the problem of change. Online Materials Change. URL: http://plato.stanford.edu/entries/change/ The Stanford Encyclopedia of Philosophy entry on change, by Chris Mortensen. Time. URL: http://plato.stanford.edu/entries/time/ The Stanford Encyclopedia of Philosophy entry on time, by Ned Markosian. Temporal Parts. URL: http://plato.stanford.edu/entries/temporal-parts/ The Stanford Encyclopedia of Philosophy entry on temporal parts, by Katherine Hawley. Material Constitution. URL: http://plato.stanford.edu/entries/material-constitution/ The Stanford Encyclopedia of Philosophy entry on material constitution, by Ryan Wasserman. Persistence Bibliography. URL: http://tedsider.org/teaching/pp_bibliography.pdf A bibliography on change and related issues, by Theodore Sider. Sample Syllabus Books on Syllabus Rea, Michael. Material Constitution: A Reader . Lanham: Rowman & Littlefield, 1997. Sider, Theodore. Four-Dimensionalism . Oxford: Oxford University Press, 2001. van Inwagen, P. and Zimmerman, D. 2008. Metaphysics: The Big Questions . 2nd ed. Oxford: Blackwell, 2008. Week 1: Time and Tense Four-Dimensionalism , chapters 1 and 2. Markosian, Ned. 'A Defence of Presentism.' Oxford Studies in Metaphysics, Volume 1. Ed. D. Zimmerman. Oxford: Oxford University Press, 2004: 47–82. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 116-123. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 124-129. Week 2: Time and Persistence Four-Dimensionalism , chapter 3. McGrath, Matthew. 'Temporal Parts.' Philosophy Compass 2 (2007): 730–48. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 265-267. Hawthorne, J, Scala, M., and Wasserman, R. 'Recombination, Humean Supervenience, and Causal Constraints: An Argument for Temporal Parts?' Oxford Studies in Metaphysics , Volume 1. Ed. D. Zimmerman, Oxford: Oxford University Press, 2004: 301-318. Week 3: Change and Presentism In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 141-149. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 267-269. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 269-281. Week 4: Change and Temporal Parts Four-Dimensionalism , pp. 92–8. Heller, Mark. 'Things Change.' Philosophy and Phenomenological Research 52 (1992): 695–704. Lombard, Lawrence. 'The Doctrine of Temporal Parts and the "No Change" Objection.' Philosophy and Phenomenological Research 54 (1994): 365–72. Week 5: Change, Relationism, and Adverbialism Hawley, Katherine. 'Why Temporary Properties are not Relations between Physical Objects and Times.' Proceedings of the Aristotelian Society 98 (1998): 211–16. Wasserman, Ryan. 'The Argument from Temporary Intrinsics.' Australasian Journal of Philosophy 81 (2003): 413–19. Lewis, David. 'Tensing the Copula.' Mind 111 (2002): 1–13. Caplan, Ben. 'Why so Tense about the Copula?' Mind 114 (2007): 703–8. Week 6: Change and Tropes Ehring, Douglas. 'Lewis, Temporary Intrinsics and Momentary Tropes.' Analysis 57 (1997): 254–8. MacBride, Fraser. 'Four New Ways to Change Your Shape.' Australasian Journal of Philosophy 79 (2001): 81–9. Simons, Peter. 'On Being Spread Out in Time: Temporal Parts and the Problem of Change.' Existence and Explanation . Eds. W. Spohn, B.C. van Fraassen, and B. Skyrms. Dordrecht: Kluwer, 1991: 131-147. Weeks 7 and 8: Special Topic – Material Change Four-Dimensionalism , chapter 5. Selections from Material Constitution: A Reader. Week 9: Special Topic – Change of Position In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 186-195. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 195-215. Week 10: Special topic – Changing the Past In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 224-235. van Iwagen, Peter. 'Changing the Past.' Oxford Studies in Metaphysics , Volume 5 . Ed. D. Zimmerman. Oxford: Oxford University Press, 2009: 1-22. Hudson, H. and Wasserman, R. 'Van Inwagen on Time Travel and Changing the Past.' Oxford Studies in Metaphysics , Volume 5. Ed. D. Zimmerman. Oxford: Oxford University Press, 2009: 41-49. (shrink)

Business schools, and universities providing business education, from across the globe have increasingly engaged in responsible management education (RME), that is in embedding social, environmental and ethical topics in their teaching and research. However, we still do not fully understand the institutional pressures that have led to the adoption of RME, in particular concerning under-researched regions like Central and Eastern Europe (CEE). Hence, we undertook what is to our knowledge the most comprehensive study into the adoption of RME in CEE (...) to date (including 13 countries: Belarus, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Russia, Slovenia and Ukraine). We find that, with regard to RME, isomorphic pressures seem to shape teaching and research in different ways, which suggests that the idea of a holistic approach to RME, promoted by, for example, the Principles of Responsible Management Education (PRME), needs to be revisited; rather, different trajectories of organizational engagement may emerge for each principle. As a contribution to institutional theory, we discuss how a highly fragmented organizational field—like RME with its multiple dimensions—impacts on notions of actor centrality, where actors achieve centrality with regard to some dimensions of the field but fail to do so for others. In particular, we found that the European Union holds centrality in the area of RME teaching, but not in RME research. Our findings thus suggest that the concept of field centrality needs further clarification. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

This chapter argues that the Covid-19 pandemic has exposed the limits of the mainstream individualistic notion of resilience and, in light of these limits, it advances a new, relational notion of the concept of resilience that contributes to the individuals’ well-being and takes into consideration the role of systemic inequality. The first half of the paper argues that the individualistic notion is flawed in two ways: i) it can foster ill-being because it is cognitively taxing, and ii) it discounts systemic (...) inequality because it transfers the responsibility of any achievement and failure onto the single individual without regard for conditions of oppression. The second half of the paper reconceptualizes the concept of resilience as a relational notion that takes into account structural support as well as conditions of oppression and marginalization. According to this latter notion of resilience, the chapter argues that oppression, lack of material conditions, or lack of structural support are elements that can impact the appropriateness of calls to be resilient. A relational notion of resilience fosters well-being because it puts the collective community at the center (instead of the individual) and it takes into consideration material conditions and structural injustices. (shrink)

Background: nursing students are required to think reflectively in both real and simulated clinical practice. Although the Reflective Thinking instrument is reliable in its measurement of reflective thinking, its validity is unknown. Method: confirmatory factor analysis was undertaken in an iterative manner within a non-equivalent control-group study to measure nursing students’ reflective thinking and satisfaction with high-fidelity simulation. The validity and reliability of the Reflective Thinking instrument was tested. Results: the resulting instrument consisted of 15 items across four factors. The (...) final model was plausible as it demonstrated ‘goodness of fit’; however, it had neither convergent or discriminatory validity, nor reliability. Internal consistency was fair to reasonable for the four subscales. Conclusion: the testing of the Reflective Thinking instrument using confirmatory factor analysis is a vital initial step in the modification of this instrument. Further development using exploratory factor analysis will enhance the instrument’s relevance within high-fidelity simulation. (shrink)

At first blush, values such as diversity appear to be worth striving for. The question is whether or not such values—which have become increasingly prevalent in university mission statements—are values as such, which is to ask whether they are things of moral worth (Value, n.d.), or are something else altogether. My unpopular suspicion leans toward the latter. Personal opinions, of course, are hardly a justification for an impassioned critique, however, my opinions mirror those held by moderate and conservative witnesses to (...) the sociopolitical climate of academia (Pew Research Center, 2017) as well as individuals who would typically be considered classically liberal such as Peter Boghossian (2021). Because of this concordance and in order to understand the constitutive relations of academic production, it becomes necessary to critically examine the nature of institutional values, separate from polemical rhetoric that either seeks to construct a "straw man" of them in order to lay them low or insulate them from outside reproach altogether Since "diversity" seems to be the chief concern among interested groups both in the academic setting and the world at large, this article's point of access to the relations of production in academia will be anchored by a Marxian assessment of diversity as a product of social labour in the academic environment. (shrink)

It has been 46 years since the publication of “Famine, Affluence, and Morality” by Peter Singer. In the paper Singer famously challenges readers to radically change their lives to save the lives of others, often in distant lands. With this paper, Peter Singer, perhaps the most famous living philosopher today, made his name and spawned the field of global justice. Although there have been improvements and successes, easily preventable deaths from poverty still occur in large numbers today. Philosophically (...) the paper has been very influential and continues to generate considerable debate. We return to Singer’s argument in “Famine, Affluence, and Morality” and make the case that the argument is incomplete in that while Singer’s position that we are morally obliged to help relieve famine, hunger, and so on is supported by his argument, his position that we act all things considered is not. (shrink)

Moral epistemology, like general epistemology, faces a regress problem. Suppose someone demands to know why I am justified in holding a moral belief. In a typical case, I will respond by citing a further moral belief that justifies it. A regress arises because, in order for this further belief to justify anything, it too must be justified. According to a traditional position in moral epistemology, moral foundationalism, the regress comes to an end with some moral beliefs. Moral foundationalism is an (...) attractive position because it promises to answer the regress problem. However, it inherits the burden of explaining why some moral beliefs have a particular privileged epistemic position – that is, why these beliefs are justified without requiring inferential support from other beliefs. The standard answer to this question is to insist that some moral beliefs have as their content propositions that are self-evident.A common way of resisting moral foundationalism is to argue from the fact of moral disagreement to the claim that no moral proposition is self-evident. I argue that while a simple version of this argument fails, this argument can be developed in such a way that it poses serious difficulties for moral foundationalism. I develop this argument by drawing on recent work in epistemology on the nature of our epistemic burdens in the face of peer disagreement. I then suggest that even if this argument does show that moral foundationalism fails, it need not have skeptical implications so long as coherentism remains a viable option in moral epistemology. Finally, I claim that this argument has implications for normative ethics. Namely, it rules out a position advocated by Peter Singer in his early work and indirectly supports the method of reflective equilibrium. (shrink)

Amie Thomasson challenges advocates of layered conceptions of reality to explain “how layers are distinguished” and “what holds them together” by “examining the world” (2014). One strategy for answering such questions is mereological, treating inter-layer relations as parthood relations, where layers exist whenever composition does, and the number of layers will be equivalent to the number of answers to Peter Van Inwagen’s Special Composition Question, while answers to his General Composition Question explain what holds the layers together (1987). Various (...) answers have been proffered for these questions, from the physicalist atomism of Richard Feynman (2015), Hilary Putnam (1958), and Kit Fine (1992) to the holism of Jonathan Schaffer (2010), the two-layer emergentism of Van Inwagen himself (1995), Tim Maudlin’s three-layered “flash ontology” (2011), and Rob Koons two-layered “thermal substances” (2019). In this PhD project, I seek to meet Thomasson’s challenge by identifying which of these proposals are compatible with plausible interpretations of quantum physics. Atomist answers may have difficulty with relativity, while holistic and emergentist models have trouble giving an account of experimental conditions. Maudlin and Koons’ views, meanwhile, may make testable predictions about the scope of entanglement. Examining the world can lead us to sharply winnow our theories about how layers are distinguished and what holds them together. (shrink)

Michael Ruses Darwinian metaethics has come under just criticism from Peter Woolcock (1993). But with modification it remains defensible. Ruse (1986) holds that people ordinarily have a false belief that there are objective moral obligations. He argues that the evolutionary story should be taken as an error theory, i.e., as a theory which explains the belief that there are obligations as arising from non-rational causes, rather than from inference or evidential reasons. Woolcock quite rightly objects that this position entails (...) moral nihilism. However, I argue here that people generally have justified true beliefs about which acts promote their most coherent set of moral values, and hence, by definition, about which acts are right. What the evolutionary story explains is the existence of these values, but it is not an error theory for moral beliefs. Ordinary beliefs correspond to real moral properties, though these are not objective or absolute properties independent of anyones subjective states. On its best footing, therefore, a Darwinian metaethics of the type Ruse offers is not an error theory and does not entail moral nihilism. (shrink)

Using Peter Wirzbicki's Fighting for the Higher Law as its analytic starting, this review essay considers the place of antislavery in the developments of American philosophy. Wirzbicki considers the role of African American Transcendentalists and their appeal to a “higher law,” a concept articulated significantly by a diverse group of thinkers associated with Transcendentalism. By 1850, such thinkers appropriated aspects of British and continental idealism, especially the relationship between “understanding” and “Reason,” to aggressively attack human chattel bondage. In doing (...) so, they not only reflected the tenets of America's broader intellectual ethos (i.e., notions of democracy) but also cultivated the ground for philosophy in the postbellum period. (shrink)